Atherosclerosis risk factors may be underestimated in patients with pulmonary hypertension associated with congenital heart disease – results of Polish snapshot registry

Abstract Introduction Classic risk factors of atherosclerosis may contribute to cardiovascular (CV) in patients (pts) with pulmonary hypertension associated congenital heart disease (PAH-CHD), but their prevalence is poorly studied. Purpose We evaluated a large cohort Polish PAH-CHD (PAHpts) treated specific therapies regard classic for atherosclerosis. Methods A multicenter observational snapshot registry was conducted under the auspices Cardiac Society study PAH pts, identified centers treating >5 such pts years 2008–2018. The analysis included 250 including non-corrected CHD – predominantly Eisenmenger Syndrome (Gr. 1, 224 mean age 42±2 years, 63% females) and after correction 2, 26 42±6.5 62% females). incidence CV compared both groups. Results considerable considering young statistically similar groups (Figure). Hypertension present 14% Gr. 1 15% 2. diabetes comparable (3% vs. 4%). Hyperlipidemia nearly numerically twice as frequent (23% 12%, p=0.18). Current smokers (1%) were only while history smoking 4% Symptomatic peripheral arteries (8% 4%, p=0,71). There no difference regarding prior stroke (3,6% vs p=0,63). Chronic kidney atrial fibrillation one half more often (respectively, 12% 8%, p=0,81; p=0.75). Mean rate 72±2 bpm 77±7 Gastrointestinal bleeding reported (2.7%). SCORE calculated risks low due age, high 9.3% 20% 2 (p=0.096). Conclusions Based on our data from national survey, are not uncommon population relatively PAH-CHD, parallel improved longevity. Selected elevated death atherosclerotic complications. This finding influence overall mortality reflects new challenges management despite progress hypertension. FUNDunding Acknowledgement Type funding sources: None. Figure